Highlights in Translational Science

Research provides the basis for the future of ophthalmology. The four sessions of this new format present clinical problems like age-related macular or dry eye syndrome are discussed under clinical and research perspectives, allowing for a more complete view. After each session, the best abstract of the session will be chosen.


 
engl
Saal Helmholtz 15:00 - 16:15 27.09.2019
Symposien Fr15
Chameleon-like Corneal Disorders – 7th joint symposium of the Cornea Society and the Sektion DOG-Kornea
There are hidden causes of corneal erosion. Forme fruste of keratoconus does not show any pathologic signs at the slit-lamp. We know distinct corneal alterations with regard to the general term of the so-called dry eye. Different forms of corneal dystrophies are striking as inflammatory clinical signs associated with recurrent corneal erosion. Acanthamoeba keratitis is often mistaken for a herpetic disease at the beginning of the disorder. Several infantile corneal signs can be a hint to distinct hereditary systemic diseases. The most important decompensation of the cornea represents the Fuchs endothelial corneal dystrophy. MGUS-induced paraproteinemic keratopathy is not well known and shows similar clinical signs with regard to distinct dystrophic, systemic, and inflammatory/immunologic alterations of the cornea. Mark Mannis (Sacramento, USA) will finally present the 3rd Oskar Fehr lecture.
Anthony J. Aldave (Los Angeles)
Walter Lisch (Mainz)
Berthold Seitz, Direktor (Homburg/Saar)
Thomas Reinhard, Klinikdirektor (Freiburg)
Gerd Geerling, Klinikdirektor (Düsseldorf)

Multiple individual and sometimes combined causes can result in corneal erosions. Trauma, dystrophies and degenerative disease are the most common forms of pathogenesis, which will be reviewed and their management described.

Michael W. Belin (Marana)

Forme fruste keratoconus (FFK) was defined as a cornea with no abnormal findings by slit-lamp examination and Placido-based topography, with a fellow eye of clinical keratoconus. In other words, an eye that appears “normal” with 70-year-old examination techniques.  The term is currently being used to categorize normal eyes with positive angle kappa, thin but normal corneas and bilateral “suspicious” maps.  This talk will review/suggest appropriate testing and terminology to minimize ambiguous terms such as FFK.

Claus Cursiefen, Klinikdirektor (Köln)

The dry eye is the most common complaint in the ophthalmological practice. Behind a "harmless" dry eye there can also be serious illnesses. Differential diagnoses are discussed.

Anthony J. Aldave (Los Angeles)

This case-based lecture will present a number of inherited and acquired corneal disorders that share phenotypic features of one or more of the corneal dystrophies. A framework for determining whether corneal opacification is likely due to a dystrophic or non-dystrophic disorder will be presented, based on history, examination findings and the results of ancillary testing.

Berthold Seitz, Direktor (Homburg/Saar)

Acanthamoeba keratitis is a rare but severe ocular disease that is becoming steadily more common. In the early stages, a diagnosis of acanthamoeba keratitis is a special challenge for ophthalmologists because the disease can present symptoms very similar to herpes keratitis or bacterial or mycotic keratitis. Despite the increased number of cases, the disease is still rarely recognized immediately. Up to 90% of patients with acanthamoeba keratitis are originally misdiagnosed. However, timely diagnosis is crucial for a good visual acuity prognosis. If the disease is identified too late, a penetrating keratoplasty is often necessary, and in severe cases, patients may be in danger of losing the infected eye. 

Wolf Lagrèze (Freiburg)

Corneal alterations in childhood may not only lead to amblyopia, photophobia or glare, but can be a hallmark of potentially serious systemic diseases. Hence, their knowledge is essential in pediatric ophthalmology. The talk will give an exemplary overview on the most important congenital and early childhood corneal disorders.

Sophie X. Deng (Los Angeles)

Cornea decompensation is a result of endothelial dysfunction. Common causes and management of corneal decompensation will be discussed.

Walter Lisch (Mainz)

Monoclonal gammopathies are much more common than previously known in Ophthalmology. In the benign form or MGUS, different corneal opacities can be observed, in which the patients having no subjective symptoms or conscious systemic findings other than the corneal opacities. It is therefore to be demanded that in all elderly patients with bilateral unclear corneal findings, serum protein electrophoresis should be performed to include or exclude monoclonal gammopathy.

Mark Mannis (Sacramento)

The corneal specialist interacts with many of the other subspecialty areas in ophthalmology, primarily due to the importance of the cornea in diagnosis and treatment. This lecture will review the critical  tangents of the cornea to pediatric ophthalmology, glaucoma, neuro-ophthalmology, retina, oculoplastic surgery, cataract surgery, and general medicine. The purpose of this lecture is to clarify for both the corneal specialist and other subspecialists in ophthalmology the critical role of the cornea in diagnosis and management.